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2021;62 doi: 10.1016/j.jddst.2020.102317

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Regulation of CD8 + T cell-mediated immune responses by amino acid metabolism Glutamine Glutamine is deaminated to form glutamate and -ketoglutarate (-KG), which supports anaplerosis of the TCA cycle and plays a crucial role in regulating histone methylation and chromatin accessibility (Fig